“设计-构建-测试-学习”循环(DBTL)是合成生物学核心研发模式，可有效地筛选和优化所需的生物合成装置和系统功能。在生物制造领域，DBTL循环四个环节循环反复，不断测试、修改直到获得所需要功能的DNA构建体。合成生物学底层技术主要应用到DNA合成技术、组装技术；基因编辑技术和体内定向进化技术。其中，基因编辑技术在基因研究、基因治疗和遗传改良等方面展示出巨大潜力。 

Pelvic floor diagnostics refers to the diagnosis of pelvic floor disorder. The pelvic floor diagnostic devices evaluate the nerve function of the pelvic floor. A pelvic floor disorder happens when the muscles or tissues of the pelvic area result in weakening or are injured. The most basic disorders of the pelvic floor are urinary incontinence, fecal incontinence, and pelvic organ prolapse.

Molecular diagnostics point of care (POC) refers to the use of molecular testing methods and technologies to rapidly diagnose diseases or conditions at or near the patient's location, rather than sending samples to a centralized laboratory for analysis. • It involves the detection and analysis of specific molecules, such as nucleic acids (DNA or RNA), proteins, or other biomarkers, that are indicative of a particular disease or condition.

According to World Health Organization (WHO), mental health is defined as a ‘state of well-being in which an individual realizes his or her abilities, can cope with the normal stresses of life, can work productively, and can contribute to his or her community.’ • Furthermore, according to MentalHealth.gov (a sub-division of the U.S. Department of Health & Human Services), mental health comprises emotional, psychological, and social well-being.

A contact lens is a thin, curved lens designed to cover the eye surface and correct vision impairments. They are used to correct vision problems caused by refractive errors or defaults.

A clinical decision support system (CDSS) is a type of health information technology that offers knowledge and person-specific data to physicians, employees, patients, and other individuals to support health and medical care. A wide range of tools are included in CDSS to improve clinical workflow decision-making. These tools include, among others, focused patient data reports and summaries, documentation templates, diagnostic support, and contextually relevant reference data.

Nearly 10 million individuals above the age of 50 suffer from hip, spine, or wrist fractures at some point in life. An additional 33.6 million individuals develop low bone mass and are at risk of osteoporosis. The growing number of complications related to bone-associated disorders such as fractures, traumas, bone infections, and bone tumors has led to the increasing demand for bone void fillers. The bone void fillers have become an indispensable tool for surgeons to manage and treat bone disorders. With the growing prevalence of bone-related diseases and accidents, many leading companies are introducing innovative solutions to provide patients with highquality bone void fillers to achieve the best outcomes.

Claudin18.2 是 CLDN 蛋白质家族的一个亚型，一般情况下仅在分化的胃黏膜上皮细胞上表达，维持胃黏膜的屏障功能。而在胃上皮组织恶性转化过程中，细胞极性的扰动导致 CLDN18.2 表 位在细胞表面暴露，CLDN18.2 在特定肿瘤组织中稳定表达，胃癌中表达率高达 80-90%，胰 腺癌表达率超过 60%。日本安斯泰来的 Zolbetuximab 单抗成功上市验证了该靶点的成药性，成为全球第一款获批的 CLDN18.2 药物。

临床数据是 Biotech 股价变化的重要催化之一。未商业化的 Biotech 公司最大的价值取决于临床管线，临床数据读出往往成为股价变化的重要催化，现整理美股部分 Biotech 公司 2024 年下半年预期公布的临床试验数据，跟踪海外公司的临床试验数据读出同样可以成为我们跟踪海外前沿进展的有效线索。