Posttraumatic osteoarthritis affects approximately 5.6 million Americans annually. Those affected are typically younger and more active than persons with primary osteoarthritis. Arthrodesis is the typical management option for persons with end-stage ankle and subtalar posttraumatic arthritis. Arthroplasty is typically reserved for elderly persons. The functional limitations resulting from any of these strategies make treatment of this young population challenging. Combat wounds frequently lead to severe lower extremity injuries. We present a series of patients with severe posttraumatic osteoarthritis of the ankle and subtalar joint after combat trauma. They were treated at our institution with an integrated orthotic and rehabilitation initiative called the Return To Run clinical pathway. This clinical pathway may serve as an alternative or adjunct to arthrodesis and arthroplasty for young patients with severe posttraumatic osteoarthritis of the ankle and subtalar joint.

关键词：康复技术；创伤性关节炎

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The current proposal aims to explore the relationship between brain function and connectivity in selective pathways/circuits, neuropsychological functioning, and cognitive rehabilitation response in Veterans with both Traumatic Brain Injury (TBI) and Posttraumatic Stress Disorder (PTSD). Toward this end, we propose a randomized clinical trial involving a cognitive rehabilitation intervention that targets improved executive functioning, with the participation of N=100 Veterans diagnosed with both TBI and PTSD (n=50 experimental/n=50 control). We have just begun recruitment three months ago and enrolled n=15 dyads of veterans and family members at this point.

关键词：康复技术；脑外伤；应激障碍；退伍军人；神经标记

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The overall aim is to conduct preliminary evaluations of new rehabilitation strategies and new functional assessment methods for homonymous hemianopia (HH) and spatial neglect (SN), disabling visual and cognitive perception conditions that commonly occur as a result of severe traumatic brain injury (TBI) and stroke. Both HH and SN prevent detection of objects on the affected side, resulting in unsafe walking and driving. Using realistic tasks in virtual environments representative of everyday mobility challenges we are evaluating a novel optical device expansion prism (EP) glasses - combined with a new computerized perceptual-motor training regimen in helping people with HH and SN detect and avoid obstacles on the affected side. In the first year we developed the training software and prepared the functional assessments. In the second year we have made excellent progress in recruiting and running participants in the main pilot study, with a total of 25 participants screened and 14 enrolled. There are about 15 visits for each participant, including about 6 visits for intensive computerized perceptual-motor training. Preliminary results are encouraging. After training there were significant improvements in the ability to accurately touch targets presented in areas of prism-expanded vision in the blind hemifield. Before training, the error in touching was 17 , which reduced significantly (p = 0.001) to only 1.0 after training (equivalent to seeing side accuracy). Blindside detection performance improved significantly when using the prism glasses both in a collision judgment task in a virtual walking simulator and a pedestrian detection task in a driving simulator. Recruitment and data collection are ongoing.

关键词：康复技术；颅脑损伤；视觉康复；感知功能康复

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Pharmaceutical is related to people's health and life safety directly, we can track and control pharmaceutical safety and quality by constructing the traceable system of pharmaceutical's whole life cycle, including raw materials, production, transportation and storage. This paper develops a pharmaceutical production management system based on RFID technology, the system realizes the drug security by RFID, puts forward a pharmaceutical coding method according to EPCgloble, constructs a scheduling method and a monitoring of the pharmaceutical production process, and then it will be traceable for the information of pharmaceutical production process.

关键词：医药；RFID；医药产品；生产管理系统

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This chapter focuses and reviews on the characteristics and bio medical application of chitosan and collagen from marine products and advantages and disadvantages of regeneration medicine. The understanding of the production processes of chitosan and colla gen and the conformation of these biomaterials are indispensable for promoting the theoretical and practical availability. The initial inflammatory reactions associated with chitosan application to hard and soft tissues need to be controlled before it can be considered for clinical application as scaffold. Further, as chitosan takes too long for biodegradation in vivo, generally it is not suitable for the scaffold for degenerative medicine in especially dental pulp tissue. The collagen extract from the scales of tropical fish has been reported to have a degeneration temperature of 35℃. The proper ties of biocompatibility and biodegradation of fish atelocollagen are suitable for the scaffold in regenerative medicine.

关键词：生物医学；壳聚糖；胶原蛋白；再生医学；海洋产品

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关键词：医药；针灸；军事医学；

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据国家统计局发布的数据，2013 年1～5月份，医药制造业实现销售收入7686亿元，同比增长19.79%；实现利润总额730亿元，同比增长17.50%，销售利润率9.51%。今年上半年，医药上市公司的并购节奏明显加快，并购案例超过20个。包括华润三九收购山东临清华威药业，仁和药业收购东科麦迪森制药，上海医药控股收购东英药业，上海莱士收购邦和药业，乐普医疗收购新帅克制药等等。

关键词：医药行业；化学原料药；化学制剂；中药饮片；中成药；医疗器械

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秋季高发传染病种类较少，我国法定传染病报告发病数较上季度减少10.35 万例，并呈逐月下降趋势。前3 季度，我国疫苗批签发量总体呈稳定增长态势。我国共签发HIB 疫苗、脊灰疫苗等27 种主要疫苗5.93 亿人份（粒、盒、瓶），同比增长5.32%，增速较上半年加快2.62 个百分点。其中，麻疹疫苗、乙肝疫苗、伤寒疫苗、霍乱疫苗、甲肝疫苗、乙脑疫苗、百白破脊灰HIB 联合疫苗、鼠疫疫苗等疫苗的批签发量增幅超过30%。1～9 月，我国生物药品制造业实现销售收入1687.80 亿元，同比增长18.2%，增速较上年同期加快2.11 个百分点。

关键词：生物药品；生物制品；供求分析；问题与风险；趋势预测；政策解读；热点研究；上市公司；关键指标

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2005年，两家美国公司提出反垄断投诉，认为中国四家维生素C生产厂自2001年下半年以来通过减少供给量来操控美国当地市场。此后，随着事件的不断“发酵”，案件进展一波三折。2013年，长达八年的国内药企涉美维生素C反垄断案再起波澜。本文回顾了该案的背景、起因、进展及初步结果，并对此案折射出的影响进行了反思。

关键词：维生素C；反垄断案

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Biosimulation is the simulation of biological processes and systems, and is aided by computers. It plays an important role in the drug discovery and development process. The drug discovery and development process can be broadly classified into the following stages: target identification, target validation, lead discovery, lead optimization, and pre-clinical and clinical testing. Biosimulation is employed during all these stages and supports decision-making. One of the key roles of biosimulation in the drug discovery and development process is that it enables trials on a virtual patient population, thereby reducing the need for clinical trials on humans and animals. Thus, biosimulation provides immense value to pharmaceutical companies in terms of reducing both R&D time and costs.

关键词：生物模拟；生物过程；系统；计算机；辅助；药物发现；开发过程

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