关键词：药品；皮肤药；市场状况

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报告以图表的形式对比分析了2013年肠胃药地区基本市场状况、各主要产品品牌分地区基本市场状况、消费者的人口构成及其分布比例、各主要产品品牌分人口组别基本市场指标、消费者的生活态度、消费者的体育运动和休闲活动等。

关键词：药品；肠胃药；市场状况

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报告以图表的形式对比分析了2013年减肥营养品地区基本市场状况、各主要产品品牌分地区基本市场状况、消费者的人口构成及其分布比例、各主要产品品牌分人口组别基本市场指标、消费者的生活态度、消费者的体育运动和休闲活动等。

关键词：药品；减肥；营养品；市场状况

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关键词：四川医药；工业产值；破千亿元

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关键词：国家发改委；调整；中成药价格；明年年初；将出台

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关键词：长春高新；开发疫苗；技术咨询；企业策划

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关键词：日本；WTO秘书处；拟修订；麻醉药品；精神药物；控制法

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Neurofibromatosis type 1 patients develop benign neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs). Growth factor receptors, particularly EGFR, have been implicated in neurofibroma formation and progression, but their precise roles and relevant signaling pathways remain unknown. We found that EGFR modifies neurofibroma-initiating cell number and promotes transformation to aggressive GEM-PNST. Unbiased insertional mutagenesis screening suggested that these effects were mediated by STAT3 signaling. Immunohistochemistry demonstrated phosphorylated STAT3 (Tyr705) in human and mouse tumors. A specific STAT3 inhibitor blocked neurofibroma-sphere formation in vitro, and reduced neurofibroma growth in vivo; STAT3 knockdown by shRNA prevented MPNST formation in vivo. Finally, reducing EGFR activity strongly reduces pSTAT3 in vivo. Thus, an EGFR-STAT3 pathway regulates neurofibroma number and neurofibroma growth, and promotes transformation.

关键词：医药；治疗技术；STAT3；纤维神经瘤

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The goal of this innovator award is to continue to develop and apply RNAi-based screening methods to discover new routes toward breast cancer therapy. The project has three goals. The first is to integrate genomic and genetic information on available breast cancer cell lines to identify tumor- specific vulnerabilities and to understand genetic determinants of therapy resistance. The second is to probe the roles of breast cancer stem cells, with a particular emphasis on microRNAs. The third is to examine genomic regions that determine familial susceptibility to breast cancer using novel, focal re- sequencing methods developed in the laboratory.

关键词：医药；治疗技术；RNAi；乳腺癌

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During the first year of this study, we have completed all case report forms, data collection sheets and informed consent documents. All necessary IRB approvals have been obtained, and all regulatory documents have been submitted to the Baltimore VA Medical Center Research Committee. A local IRB modification has been submitted to clarify exclusion criteria as it relates to the assessment of diabetic subjects. All personnel have obtained appropriate certifications in order to participate in research. Multiple meetings have occurred, both in person and via teleconference in order to coordinate activities between the Baltimore and the Atlanta sites. The research protocols have been initiated, with nine individuals screened and seven progressing to study participation. In Baltimore one participant completed 3 month outcome data assessment and crossed over to the other exercise arm. The other six individuals are in the first exercise arm. Two enrollees at the Baltimore site were withdrawn from the protocol, one because of a burning sensation in the left foot during Lokomat participation, and the other because of asymptomatic blood pressure elevation during Lokomat training. At the end of year one, the research has not as of yet produced any presentations or published reports, but this was not expected.

关键词：医药；治疗技术；脊髓损伤；水生治疗

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