Partial contents: Editorial: the mental health of our deploying generation, Summary of mental disorder hospitalizations, active and reserve components, U.S. Armed Forces, 2000-2012 Surveillance Snapshot: anxiety disorders, active component, U.S. Armed Forces, 2000-2012. Mental disorders and mental health problems among recruit trainees, U.S. Armed Forces, 2000-2012. Surveillance Snapshot: mental disorder hospitalizations among recruit trainees, U.S. Armed Forces, 2000-2012. Malingering and factitious disorders and illnesses, active component, U.S. Armed Forces, 1998-2012. Surveillance Snapshot: conditions diagnosed concurrently with insomnia, active component, U.S. Armed Forces, 2003-2012.

关键词：焦虑;住院治疗;药物;精神障碍;心理健康;招聘;报告;监测;学员

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Despite suicide being a leading cause of death among new mothers during the postpartum period, there has been limited research on self-harm in the postpartum period and associated risk factors. One potential risk factor for suicidality (completed suicides, suicide attempts, and suicide ideation including thoughts of self harm) during the postpartum period is postpartum depression (PPD). Between 1 January 2007 and 31 December 2012, 5,267 (9.9%) active component service women and 10,301 (8.2%) dependent spouses were received with an incident PPD diagnosis during the postpartum period; 213 (0.4%) service women and 221 (0.2%) dependent spouses were diagnosed with incident suicidality. Aft er adjusting for the eff ects of other covariates, service women with PPD had 42.2 times the odds of being diagnosed with suicidality in the postpartum period than service women without PPD; dependent spouses with PPD had 14.5 times the odds compared to those without PPD. Th e fi ndings of this report suggest that history of mental disorders was common among service women and dependent spouses with PPD in the postpartum period, and, in turn, PPD was a strong predictor for suicidality in the postpartum period. Th ese results emphasize the importance of PPD screening during the postpartum period. Th is also suggests that additional focused screening for suicidal behavior among those already diagnosed with PPD may be warranted.

关键词：医学;心理健康;创伤后应激障碍;自杀;焦虑;女性;历史;住院;炎症;精神障碍;卵巢;招聘;报告;监测;培训

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关键词：脊柱,攻击直升机,脖子(解剖);职业医学;疼痛;飞行员;旋转翅膀;Apache,背部疼痛,颈部疼痛纵向研究

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Epigenetic alterations offer promise as diagnostic or prognostic markers, but it is not known whether these measures associate with, or predict, clinical state. These questions were addressed in a pilot study with combat veterans with PTSD to determine whether cytosine methylation in promoter regions of the glucocorticoid related NR3C1 and FKBP51 genes would predict or associate with treatment outcome. Veterans with PTSD received prolonged exposure (PE) psychotherapy, yielding responders (n D8), defined by no longer meeting diagnostic criteria for PTSD, and non-responders (n D8). Blood samples were obtained at pre-treatment, after 12weeks of psychotherapy (post-treatment), and after a 3-month follow-up. Methylation was examined in DNA extracted from lymphocytes. Measures reflecting glucocorticoid receptor (GR) activity were also obtained (i.e., plasma and 24 h-urinary cortisol, plasma ACTH, lymphocyte lysozyme IC50-DEX and plasma neuropeptide-Y). Methylation of the GR gene (NR3C1) exon 1F promoter assessed at pre-treatment predicted treatment outcome, but was not significantly altered in responders or non-responders at post- treatment or follow-up. In contrast, methylation of the FKBP5 gene (FKBP51) exon 1 promoter region did not predict treatment response, but decreased in association with recovery. In a subset, a corresponding group difference in FKBP5 gene expression was observed, with responders showing higher gene expression at post-treatment than non-responders. Endocrine markers were also associated with the epigenetic markers. These preliminary observations require replication and validation. However, the results support research indicating that some glucocorticoid related genes are subject to environmental regulation throughout life. Moreover, psychotherapy constitutes a form of environmental regulation that may alter epigenetic state. Finally the results further suggest that different genes may be associated with prognosis and symptom state, respectively.

关键词：胞嘧啶;甲基化;创伤后应激障碍;蛋白质;心理;细胞(生物学);人口;脱氧核糖核的酸;基因表达;淋巴细胞;统计分析;退伍军人

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Information is widely recognized as the lifeblood of modern medicine. Health information technology (health IT) has the potential to improve the flow of information across the health care system and serve as the infrastructure to enable care transformation. Health IT comprises technologies--from electronic health records (EHRs) and personal health records (PHRs) to remote monitoring devices and mobile health applications--that can collect, store, and transmit health information. By enabling health information to be used more effectively and efficiently throughout our health system, health IT has the potential to empower providers and patients; make health care and the health system more transparent; enhance the study of care delivery and payment systems; and drive substantial improvements in care, efficiency, and population health.

关键词：卫生信息技术;信息交换;医疗记录;医疗保健服务;医疗计算机应用;监测;患者;支付;人口;电子健康记录

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Androgen receptor (AR)-mediated transcription is modulated by interaction with co-regulatory proteins. We identified a novel AR repressor complex comprising of the androgen receptor co-repressor Art-27 and the transcriptional repressor URI. We found through chromatin immunoprecipitation experiments that URI depletion results in increased H3K9me3 at the promoter of the AR target gene Nkx3.1, suggesting that one mechanism of URI-mediated transcriptional repression is through chromatin modification. Art-27 was also found by ChiP to localize at the transcription start site of Nkx3.1 along with PolII. Previous results demonstrated a direct interaction between URI and the transcription factor KAP1. Because of the tight association of Art-27 with URI, we hypothesized that Art-27 also affects KAP1 activity. Immunoprecipitation of Art-27 with KAP1 revealed a direct interaction between the two proteins. Consistent with this result, knockdown of Art-27 resulted in increased expression of the KAP1 targets LINE1 and AluYa5. Overall, our findings demonstrate a new role for Art-27 in KAP1-mediated gene repression.

关键词：雄激素;细胞(生物学);增长(生理学);受体网站(生理学);泌尿系统;化学沉淀;芯片(电子);染色质;损耗;基因;免疫;蛋白质;感觉器官;目标;Ar介导细胞生长;前列腺癌进展

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Despite the fact that there have been significant developments in anti-cancer technology, ovarian cancer still remains one of the leading causes of gynecological cancer deaths in the United States. To contribute towards novel approaches with minimal toxicity in treatment of ovarian cancer we proposed the present work, where we are integrating the field of nanotechnology with ovarian cancer cells unique property of overexpressing folic acid receptor alpha (FR- ) to specifically target ovarian cancer. A cerium oxide nanoparticle, called Nanoceria (NCe), that has the ability to act as an anti- oxidant in similar capacity as biological anti-oxidants was selected. NCe in our hands exhibited efficacy in inhibiting ovarian tumor growth in vivo. Taking advantage of the nanotechnology, NCe was conjugated with molecules of folic acid to specifically target ovarian tumors as they are known to over-express folate receptor. This would result in specific killing of ovarian cells by NCe while minimizing toxicity to normal tissue. Dr Seal s laboratory (UCF) was able to successfully conjugate NCe to folic acid to prepare folic acid tagged Nanoceria called FA-NCe. FA-NCe was tested in vitro and was observed to have higher anti-growth activity against ovarian cancer cells. When given in animals, FA-NCe was more potent in inhibiting ovarian tumor growth than NCe alone.

关键词：叶酸;卵巢癌;抗氧化剂;细胞(生物学);临床医学;增长(生理学);体外分析;体内分析;标记物质;肿瘤;卵巢;效力;感觉器官,测试和评估;毒性

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No abstract available.

关键词：急性呼吸道疾病病毒,腺病毒;军队结核病控制项目,部署相关条件;消除,招募人员,癫痫;免疫;军事力量(美国),军事医学;再版;肺结核

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关键词：军事力量(美国),性病,沙眼衣原体;免疫;医疗筛查;淋病奈瑟氏菌;韩国;统计;疫苗;人类乳头状瘤病毒;生殖器疣

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No abstract available.

关键词：现役;部署;传染病;嗜肺性军团菌;军事力量(美国),军事人员;泌尿系统;创伤和损伤

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