Most patients with multiple myeloma achieve a complete or near complete response following autologous transplantation. However, patients experience disease relapse from a persistent reservoir of chemotherapy resistant disease.

关键词：骨髓瘤;干细胞;疫苗;抗体;能力(数量);细胞(生物学);临床医学;树突结构;疾病;免疫;免疫;免疫学、免疫抑制、免疫疗法;体内分析;模型;肿瘤;患者;储层;耐药性;响应

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As the incidence of spinal cord injury has increased in the combatant military population, improved methods of treating this clinical condition are necessary. 

关键词：脊髓;创伤和损伤;临床医学;组织病理学;氧气;感官

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The beneficial effects of soy on established breast cancer is controversial. The goal of this research is to investigate the potential molecular mechanisms by which soy isoflavones affect established breast cancers. 

关键词：乳腺癌;转移;大豆蛋白;解剖模型;分析;合成;细胞(生物学);基因;增长(通用);假设;酮类;实验室;荧光素酶;代谢物;分子性质;肿瘤;蛋白质;反应;生存能力;合成

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The purpose of this work is to better understand the mechanisms of resistance to androgen biosynthesis inhibitors in men with castration resistant prostate cancer, and to investigate clinical methods of overcoming resistance.

关键词：前列腺癌;乙酸盐;雄激素生物合成;血液计数;临床医学;沿海地区;细胞化学;脱氧核糖核的酸

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This application focuses on enhancing cancer care by developing non-invasive techniques to determine better biomarkers to improve diagnostic specificity and decrease the number of negative biopsies, and also as markers of response with novel targeted agents such as Trastuzumab and Bevacizumab. Last year, we optimized lactate sequence (SS1-SelMQC) using higher order binomial pulses with better lipid suppression compared to original SS-SelMQC and started working on breast tumors. In this year, we completed data collection of lactate MR spectroscopy data of in vivo breast tumors with different expression levels of ER, PR, HER-2 as a function of Herceptin and Avastin. We completed quantification of 1D spectra and made significant progress in 2D quantification to explain tumor heterogeneity, an important step towards understanding treatment response. Presently, we are working on completing the data analysis of all 2D data analysis simultaneously along with the histological correlation.

关键词：癌;活检;检测;诊断（医学）;肿瘤

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My laboratory has continued to study the role of the novel molecular target, Fyn, in prostate cancer. In this second year of DoD funding we have made significant progress in defining the Fyn signaling pathway and its relationship with Met: a novel and important molecular target in several diseases including prostate cancer. Also, we have completed an important initial battery of murine studies showing an effect on dissemination: When Fyn deficient tumor cells were injected in vivo, their ability to metastasize was significantly diminished. Our studies continue to support the importance of Fyn as putative therapeutic target in advanced prostate cancer. This has become critically important given the recent report by Araujo of the long awaited phase 3 study of docetaxel with or without dasatinib, a Src-family kinase (SFK) inhibitor. The disappointing results have threatened the viability of applying SFK inhibition to the disease of prostate cancer. My group and others still believe that the completed study failed to translationally address the relevant biology of Fyn and SFKs in prostate cancer. Clinical studies with translational endpoints are now being planned with agents that effectively inhibit Fyn and Met in a variety of settings.

关键词：转移;前列腺癌;细胞临床医学;疾病;分布;体内分析;抑制;肿瘤;报告;信号;治疗

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Based on our published data we propose that specific patterns of genomic copy number alterations (CNAs) occur in prostate cancer in African American (AA) men which are associated with different levels of disease aggressiveness. 

关键词：前列腺癌;非裔美国人;基因;基因;高速率;肿瘤

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A self-calibrating even-order distortions technique is presented whereby different mechanisms responsible for even-order distortions, characterized by IIP2 metric (Second Harmonic Input referred Intercept Point), were independently calibrated, resulting in robust performance independent of the amplitude and frequency of the blocker. Second, an active dynamic blocker-notching scheme is proposed and tested.

关键词：无线接收器；干扰管理；输入二阶截取点；CMOS

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We present a new approach for fast sheared filtering on the GPU. Our algorithm factors the 4D sheared filter into four 1D filters. We derive complexity bounds for our method, showing that the per-pixel complexity is reduced from O(n^2 l^2) to O(nl), where n is the linear filter width (filter size is O(n^2)) and l is the (usually very small) number of samples for each dimension of the light or lens per pixel (spp is l^2). We thus reduce sheared filtering overhead dramatically. We demonstrate rendering of depth of field, soft shadows and diffuse global illumination at interactive speeds. We reduce the number of samples needed by 5 ? 8×, compared to axis-aligned filtering, and framerates are 4× faster for equal quality.

关键词：交互渲染；4D；修剪过滤；傅里叶分析

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Taking into account the limited power budget, this research investigates the design choices of the number of elements in phased-array transceivers, and identifies that the overhead power is the bottleneck of energy efficiency. In order to reduce the overhead power in the transmitter, a new architecture using a fast start-up oscillator is proposed, which eliminates the need of explicit modulator and 60GHz LO delivery.

关键词：无线通信；60GHz；CMOS；相控阵

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