四联苗：民海生物上周批签发58 万支，2020 年初至今批签发155万支，因行业事件影响去年同期无批签发记录，目前四联苗批签发回归正常节奏，预计2020 年销量有望达到600 万支。

随着现代生物技术的开发和应用日趋广泛，主观上或无意中对生物安全造成威胁的情况时有发生，生物安全法的推出具有现实意义。我国生物安全法草案于2019年10月21日首次提请人大常委会审议，2020年2月14日习近平发表重要讲话，要求“尽快推动出台生物安全法，加快构建国家生物安全法律法规体系、制度保障体系”。生物安全法立法加速，有望在近期推出。

With the increasing prevalence of skin cancer, there are multiple options for patients, through which they can manage the disease. The type of treatment the patient receives may depend on the cancer stage the patient has. For decades, the conventional anti-cancer treatment strategies have been surger y, chemotherapy, and radiotherapy. The recent years’ success of cancer immunotherapy, including monoclonal antibodies (mAbs), adoptive cancer therapy, and the immune checkpoint therapy, has revolutionized the traditional cancer treatment. Currently, there are several studies going on to develop the vaccine for skin cancer. For instance, researchers at Tel Aviv University, Israel, have developed a novel nano-vaccine for melanoma (2019). As of now, their innovative approach has been proven effective in the mouse model. This approach has given an opportunity for the innovation companies to establish their market presence in the near future, with the help of providing a vaccine for skin cancer.

The past two decades have witnessed rapid technological advancements and development of robots for rehabilitation applications, such as in sensorimotor deficits resulting after damage to the central nervous system. The increasing cases of these types of problems across the world have led to the development of innovative rehabilitation robots coupled with advanced interaction controls and the usage of integrated sensors to constantly monitor and adapt the support to the actual state of patients. These rehabilitation robots are helping patient's recovery by assisting and encouraging upright walking and by relearning of lost functions for patients affected by stroke and paralyses. According to a study by Maxon Motor AG, the company estimated that approximately 185 million people use a wheelchair daily, worldwide. Since the advent of first clinical studies with the MIT-Manus robot, robotic applications have been increasingly used to restore loss of motor function, mainly in stroke survivors suffering from an upper limb paresis but also in cerebral palsy, multiple sclerosis, spinal cord injury, and other disease types. Thus, numerous studies suggested that robot-assisted training, integrated into a multidisciplinary program, resulted in an additional reduction of motor impairments in comparison to usual care alone in different stages of stroke recovery.

The report provides market dynamics and trends related to the global premenstrual syndrome treatment market. In addition, it presents the estimations and forecast of the market. The study estimates the revenue generated from the sales of premenstrual syndrome therapeutics; however, it excludes the premenstrual syndrome treatment service revenue. Valuations comprise revenue generated from approved and off label drugs such as analgesics, antidepressant, oral contraceptives, and ovarian suppression agents. Furthermore, the report excludes revenue generated from post-sale services of the premenstrual syndrome treatment market.

The insulin sensitizing agent segment was the highest contributor to the market, with $1,030.5 million in 2018, and is estimated to reach $1,449.5 million by 2026, at a CAGR of 4.3% during the forecast period. The oral contraceptive segment is estimated to reach $1,235.2 million by 2026, at a CAGR of 5.7%. The insulin sensitizing agent and oral contraceptive segments collectively accounted for around 62.8% market share in 2018, with the former constituting around 35.5% share. The oral contraceptive and antiandrogens segments are expected to witness significant CAGRs of 5.7% and 5.1%, respectively, during the forecast period. The cumulative share of these two segments was 43.8% in 2018, and is anticipated to reach 46.4% by 2026.

2020年初的带量采购至今仍让人印象深刻：大幅降价、龙头洗牌，似乎仿制药领域不确定性成为最大的确定性，集采相关的仿制药标的成为“需短期规避”的重点品种。带量采购对中标企业、非中标企业和药品子行业，带来了怎样的影响？我们利用样本医院销售数据，复盘分析了2018年底4+7集采的样本在2019年的销售额、竞争格局的变化，发现带量采购加速了一致性评价背景下国产仿制药替代率提升，中标品种和中标企业大部分实现了以价换量，而以价换量将成为过渡期仿制药龙头业绩弹性的主要来源。复盘日本、印度龙头制药公司的发展历程，创新药研发需要科研人才、充沛的现金流、科研技术和时间的积累，从大宗仿制药，到高端仿制药，从me-too，到me-better，再到突破性的创新药品种的发展道路，往往更常见也更现实。在中国市场化、国际化竞争过渡的大环境中，创新药诚然会成为未来制药行业的核心竞争力，但短期内也要重视一致性评价、带量采购所加速的仿制药替代率提升、以价换量，对相关公司现金流、业绩的强力支撑。

Teeth play a vital role in the maintenance of a positive self-image and appearance. While the loss of teeth may result in a significant change in the appearance of a person that can profoundly disrupt one’s confidence. A missing tooth can change facial aesthetics, which can lead to loss of bone, which may impact facial expressions leading further to social stigma. Hence, many people opt for dental implant treatments, which help to boost their self-confidence. Tooth loss may be traumatic and upsetting and is regarded as a serious life event that requires significant psychological and social readjustment. Tooth loss is very common, especially in the adult population, and can happen as a result of decay, gum disease, and injuries/accidents. Also, few people are born without certain teeth, which is called congenitally missing teeth and is due to genetic factors. As per the American Association of Oral and Maxillofacial Surgeons (AAOMS), 69% of people aged between 35 and 44 years have at least one permanent tooth due to gum disease, accidents, a failed root canal, or tooth decay. Further, as per the organization, 26% of people above 74 years of age have lost all of their permanent teeth.

The report covers the detailed analysis of the trends, future estimations, and a thorough study of the Asia- Pacific market on the basis of type, ingredients, and distribution channel. It analyses government regulations, policies, and patents to provide information on the current market trends in Asia-Pacific regions and suggests future growth opportunities. This in turn increases consumer acceptance in that region. The study highlights Porter’s five forces analysis to determine the factors affecting the market growth. These factors include raw material prices, intense competition, end users, manufacturers, and suppliers. To understand the market, drivers, restraints, and opportunities are explained in the report. Furthermore, it includes the revenue generated from the sales of baby infant formula across China, India, South Korea, Japan, Philippines, Indonesia, Australia, New Zealand and Rest of Asia-Pacific.

企业采浆与销售增速倒挂，龙头企业库存已处于低位。自2017 年血制品行业进入去库存周期后，生产企业放缓对采浆的投入力度，2019年预计采浆量约9100 吨，同比增速仅5.8%，我国血制品行业原料血浆供给增速放缓。