硬件创新和软件创新走向融合。中国电子产业地位正在快速提升。从产品创新和制造升级两位维度选择投资机会。1）从产品创新的角度，前瞻性布局可穿戴和移动支付领域；2）从产业升级的角度，重点布局享受工程商红利的安防产业，核心零部件获得突破的光学膜、玻璃基板产业；3）从行业周期的角度，布局LED 和半导体产业。

关键词：硬件创新；软件创新；中国电子产业；产品创新；制造升级

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光伏：向上周期明确，布局细分行业龙头与电站相关企业。空间大。新能源汽车：行业新发展，关注锂电与AGM电池。配网：分布式能源+新型城镇化→精选配网优质公司。

关键词：光伏；新能源汽车；配网

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The complete annual report for 1977 gives information on supported projects in the Program for Energy Research and Technologies, 1977--1980 of the Federal Government excluding projects relating to nuclear energy and fusion research; it is broken down into three subprograms: (1) efficient use of energy in application and in secondary energy; (2) coal and other fossil sources of primary energy; (3) new sources of energy. This document presents only subprogram (3), new sources of energy, as excerpted from the overall annual report, namely: development of new energy sources (solar energy, wind energy, geothermal energy) through ascertaining energy availability and its regional distribution; development of technologies for use and conversion; and demonstration of technical and economic feasibility. Ninety-four projects are described, including objectives, funding, and status. Additional information on the projects is included in appendix.

关键词：太阳能；新能源；地热能源；波浪发电

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关键词：研发；智能；捞油机

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Tamoxifen, the first targeted therapy, has shown great success in treating estrogen receptor (ER) positive breast cancer. However, both acquired and de novo resistance to this therapy prevents it from being effective in all situations. Multiple lines of evidence indicate that increased signaling through growth factor pathways, such as the IGF pathway, mediates resistance to tamoxifen. The link between ER and ICGF1R leads us to hypothesize that IGF system crosstalk with the ER contributes to tamoxifen resistance. Tamoxifen resistance has thus provided researchers with a reason to investigate other growth factor pathways involved in breast cancer. As new targeted therapies are being developed, it will be important to examine their benefit with existing therapies. In order to examine the effectiveness of anti-IGF1R inhibitors in vitro, tamoxifen resistant (TamR) cells were generated by culturing MCF-7L and T47D cells in the presence of 4-OH-tamoxifen for >6 months. TamR cells had dimished levels of IGF1R, with unchanged levels of insulin receptor (IR). Further, TamR cells failed to respond to IGF-I induced p-AKT activation, while retaining responsiveness to both insulin and IGF-II. Additionally, IGF-I failed to enhance the proliferation and anchorage-independent growth of TamR cells; however, both insulin and IGF-II were able to enhance proliferation in MCF anchorage-independent growth. An IGF1R antibody was effective in inhibiting signaling, anchorage-independent growth, and proliferation in MCF-7L cells, but had no effect in TamR cells. In contract, an IGF1R/TR tyrosine kinase inhibitor was effective in both MCF-7L and TamR cells. In a xenograft model, an IGF1R antibody was able to inhibit estrogen stimulated tumor growth, but had no additive effect when combined with tamoxifen treatment. Further, tamoxifen-treated xenografts had diminished IGF1R levels.

关键词：医药；治疗技术；类胰岛素生长因子受体；抗雌激素受体

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建材行业内部分化将加大。水泥行业：景气度有望继续回升，关注优势区域。玻璃行业：复苏困难重重。新型建材：布局成长型个股。

关键词：建材行业；内部分化；水泥行业；玻璃行业；新型建材

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为提高猴头菌菌株CB1锰过氧化物酶(MnP)基因的表达产量,采用PEG/CaCl2介导的原生质体转化方法,将携带有He-mnp1的重组质粒pLB01/He-mnp1转入到构巢曲霉尿嘧啶尿苷营养缺陷菌株TN02A7的原生质体中,获得了转化子菌株TN02A 7-He-mnp1,并在乙醇脱氢酶启动子alcA(P)控制下实现了异源表达.将TN02A7-He-mnp1、TN02A7、构巢曲霉野生型菌株WJA01、猴头菌菌株CB1在相同的木质素环境下进行培养并检测MnP酶活性,结果表明:转化子菌株TN02A7-He-mnp1在0.05 g· L-1血红素的情况下、诱导96 h后酶活性最高为38.31 U·L-1,比不添加血红素的酶活力高8.64倍,但比猴头菌菌株CB1的酶活力低,而TN02A7与WJA01始终无MnP酶活性,说明基因He-mnp1已经成功地被转化到TN02A 7-He-mnp1中,并在木质素环境下得到表达,血红素是重组MnP基因异源表达的限制性因素之一.本文为生产MnP和提高MnP产量提供了新的途径.

关键词：猴头菌;锰过氧化物酶;构巢曲霉;转化;表达;Hericium erinaceum;manganese peroxidase;Aspergillus nidulans;transformation;expression

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以溴代苯为溶剂,氢氧化钾为缚酸剂,在氯化亚铜-L-脯氨酸体系中吲哚和溴代苯经偶联反应得到1-苯基吲哚,探索了其影响因素.结果表明目标产物1-苯基吲哚的最佳工艺条件为:溴代苯为溶剂和原料,吲哚与溴代苯、氢氧化钾、氯化亚铜和L-脯氨酸的摩尔比为1∶9.5∶2∶0.1∶0.1,150℃反应8h,收率为91.5％,HPLC纯度为98.5％.实验证明,此反应条件温和,反应易于控制,产品收率和纯度高.

关键词：吲哚;溴代苯;1-苯基吲哚;合成;indole;bromobenzene;1-phenylindole;synthesis

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研究了无溶剂体系固定化1,3-特异性脂肪酶Lipozyme RM IM催化棕榈酸和山茶油酸解反应中,棕榈酸在产物甘油三酯中Sn-2位的相对含量分布以及酰基转移规律.考察了酶用量、底物摩尔比、酶水分活度、反应温度和反应时间对酸解反应的影响.结果表明:酶水分活度、反应温度和反应时间对棕榈酸在产物甘油三酯中的含量影响不大,对酰基转移影响较大；在酶水分活度0.550,反应温度60℃,反应时间1h的反应条件下,酰基转移的程度最小；底物摩尔比和酶用量对酰基转移的程度影响不大.

关键词：1,3-特异性脂肪酶;酸解;酰基转移;无溶剂体系;1,3-regiospecific lipase;acidolysis;acyl migration;solvent-free system

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关键层运动对采场矿压显现、覆岩移动与地表沉陷及采动裂隙场分布有着重要的意义,为了确定梅花井矿关键层位置,文章采用矿压观测、岩石密度试验、单轴压缩及变形试验等方法,确定梅花井矿601大采高工作面覆岩力学性质和周期来压特征,并通过计算机编程计算硬岩和关键层.结果说明C6岩层为主关键层,C8为亚关键层,C6关键层步距为17.88m,与矿压观测结果对比,基本顶来压步距为13～26m,两者结果比较吻合.

关键词：关键层;硬岩;基本顶来压步距;大采高;key stratum;hard rock;weighting interval of main roof;high cutting

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