The market is witnessing a trend wherein many large manufacturers,particularly of automotive components, are moving toward low-cost

manufacturing havens such as China, India, and Thailand. Government initiatives like the Make in India will provide the thrust to the manufacturing sector in India and thus, manufacturing in the overall APAC region. Thailand’s ascendancy as an automotive manufacturer and the emergence of Indonesia as another manufacturing hub in the region will drive growth in the metal cutting machine tools market; thus, APAC will emerge as the leading market for metal cutting machine tools.

Special regulatory designations will act as a major boost for the global metabolic disorders therapeutics market. These special designations help vendors launch their drugs quickly into the market. Also, in a few cases, governments offer tax incentives for such drugs. The US Food and Drug Administration (FDA) gave the orphan drug designation for a few already approved drugs such as Elelyso,

Zavesca, and Cerezyme. Regulatory bodies, at times, give these designations to pipeline products. For instance, Amicus Therapeutics' migalastat is under regulatory review in the US. However, the drug received orphan designation from the FDA for Fabry disease in June 2016.Oral insulin products are under investigation and, once approved, will emerge as new generation drugs for diabetes management. Generex Biotechnology Corporation’s Oral-lyn, Oramed Pharmaceutical's ORMD-0801 and ORMD-0901,and Biocon’s IN-105 are the upcoming oral drugs for the treatment of diabetes.

In 2015, the orthopedic applications accounted for the largest market share of 30.08%. The increasing incidence of diseases such as musculoskeletal disorders,obesity, trauma, osteoporosis, and other orthopedic conditions among the aging population is one of the primary drivers for the acceptance of medical ceramics.Asia-Pacific (APAC) is the fastest growing market for medical ceramics, with China and India being the leading countries. The market in the region is foreseen to grow at a CAGR of 8% to reach $4.35 million by 2020. China is the leading manufacturer of ceramic products worldwide. Apart from China and India, Japan, Indonesia, and Australia are the countries that account for a considerable demand in the region.The demand for medical ceramics in APAC is on the rise due to the rising incidence of trauma and orthobiological injuries.In 2015, bioinert materials accounted for a share of 39.92% in the market. These

bioinert materials are used as substitutes for metallic implants. Bioinert materials are also used in the manufacture of orthopedic implants as they show remarkable hardness.

The global mechanical computer-aided design (MCAD) market is expected to grow at a CAGR of 7.46% during the forecast period. It is highly driven by manufacturing industries in the US. The major benefit of using MCAD software is that it helps reduce the product development time.A major trend in the market is the integration of electronic computer-aided design (ECAD) and MCAD, which is expected to advance during the forecast period.Various developments in the modeling of CAD software is another major trend in the market.The global MCAD market is fragmented with a large number of major and minor players. Most of the major players are based in the US.

Retaining the interest of the customer is one of the biggest challenges faced by the global online e-commerce vendors. The e-commerce vendors do not have much control on an individual's buying decision and end up losing their prospective customers if the website or app is not user-friendly. In such an instance, mcommerce plays a vital role as it enables a customer to make a purchase with the one device that is always with them, i.e., cellphone  F-commerce, buying and selling through the social media platform Facebook, is emerging as a trend in the online retail market. It is gaining high traction due to the increased number of active Facebook users, which increased from 1.39 billion in 2014 to 1.5 billion in 2015.

The glass fiber reinforced plastics (GFRP) segment accounted for the largest market share of 82.02% in 2015. This significant market share is attributed to lower cost, easy availability, and advanced specifications of GFRP that are used in making hull and interior body parts of boats and cruise ships.Polyester was mainly consumed in the manufacturing of marine composites and accounted for 48% of the market in 2015. This high share is due to the low cost of polyester composite and its ease of use as marine composites.The powerboats segment accounted for the largest market share of 55.14% in 2015. This significant market share is attributed to the technological advancements in this sector. The key drivers for the increasing demand for marine composites in powerboats are the rise in demand for high-speed boats and increasing use of fuelefficient marine transports in recreation activities.

Around 4%-6% of the global population is affected by lower back pain, and also the number of spondylolisthesis cases in gymnasts, weight lifters, and football linesmen and women is on the rise. Surgeons estimate that one in 10 individuals suffering from spine disorders

require surgery. In the US, about 450,000 spinal fusion procedures were performed in 2015, which corresponds to about 0.13% of the

US population. The average cost of lumbar spine fusion procedure is about $34,500. Total spine fusion procedures generated about $15.3

billion in the US in 2015. It was estimated that about 84% of the bone grafts are used in spine surgeries (spinal fusion procedures) to relieve back and neck pain. This rise in the number of spinal fusion surgeries will result in increased sales of lumbar spine fusion devices.

The chat software industry is in its evolving stage; the market for live chat software is yet to be fully grown in Europe and APAC. The adoption rate of live chat software is increasing among end-users. For instance, the number of users of LiveChat solution, one of the leading live chat software providers, increased by 794 in two months (June and July 2016). The major end-users include enterprises and

universities. The clients of live chat software range from small on-line stores to global brands such as Pizza Hut, AirAsia, Kaspersky Lab, Orange, Adobe,Samsung, and Tele2.Vendors such as SnapEngage and LiveChat are adding more features, such as knowledge database integration, language support for different countries or regions, and automatic reporting to enable users to monitor real-time activity, into their software. Such activities by vendors will drive the market during the forecast period.

BMI View: Bulgaria represents one of the smallest medical device markets in the EU. We expect it to register a mid single-digit local currency CAGR over the 2015-2020 period. The market is largely reliant upon imports which are primarily sourced from other EU member states. Market growth will be dependent upon increasing healthcare funding and the success of efforts to develop the private sector.