This report presents nationally representative estimates and trends for infertility and impaired fecundity-two measures of fertility problems among women aged 15-44 in the United States. Data are also presented on a measure of infertility among men aged 15-44. Data for this report come primarily from the 2006-2010 National Survey of Family Growth (NSFG), which consisted of 22,682 interviews with men and women aged 1544, conducted from June 2006 through June 2010. The response rate for women in the 2006-2010 NSFG was 78 percent, and for men was 75 percent. Selected trends are shown based on prior NSFG years. The percentage of married women aged 15-44 who were infertile fell from 8.5 percent in 1982 (2.4 million women) to 6.0 percent (1.5 million) in 2006-2010. Impaired fecundity among married women aged 15-44 increased from 11 percent in 1982 to 15 percent in 2002, but decreased to 12 percent in 2006-2010. Among all women, 11 percent had impaired fecundity in 2006-2010. Both infertility and impaired fecundity remain closely associated with age for nulliparous women. Among married, nulliparous women aged 35-44, the percentage infertile declined from 44 percent in 1982 to 27 percent in 2006-2010, reflecting greater delays in childbearing over this period. Among married women in 20062010, non-Hispanic black women were more likely to be infertile than non-Hispanic white women. Some form of infertility (either subfertility or nonsurgical sterility) was reported by 9.4% of men aged 15-44 and 12% of men aged 25-44 in 2006-2010, similar to levels seen in 2002.

关键词：不孕不育；繁殖力；公众健康；医药

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Rhodium-105 is an attractive nuclide for radiotherapeutic applications due to its nuclear properties (566 keV beta-.gamma = 319 keV 19%), (306 keV 5%) and the kinetic stability of Rhodium (III) complexes with soft sulfur donor atoms.

关键词：前列腺癌；放射性同位素；铑；医药

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No abstract available.

关键词：毒理学；对健康的影响；1 - 乙烯基咪唑；医药

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No abstract available.

关键词：毒理学；1-3苯二甲酸；5 - 磺基；医药

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No abstract available.

关键词：1-2-3-Orioabetriol；急性毒性；慢性毒性；医药

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No abstract available.

关键词：毒理学；1 - 乙烯基咪唑；大鼠；医药

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No abstract available.

关键词：毒理学；口服毒性；医药

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No abstract available.

关键词：毒理学；对健康的影响；锍化合物；藻类；医药

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While much advancement has been made in breast cancer treatment, metastatic breast cancer remains an incurable disease. MUC1 is a glycoprotein expressed on normal glandular epithelial but is over-expressed and underglycosylated in over 90% of human breast tumors and 100% of metastatic lesions, which lead to its ranking by NCI as the second most targetable antigen. Vaccines against tumor antigens have several benefits, including the chance to eliminate metastatic lesions that express the vaccinating tumor antigen. To this end, we have proposed vaccinating with peptides from the MUC1 protein core, which is only visible to the immune system on the tumor- associated form of the protein. Previous work from our lab has demonstrated that this vaccine does elicit a MUC1-specific immune response that can only be functional if the immunosuppressive tumor microenvironment is altered to allow efficient killing of tumor cells. Thus, we investigated the effectiveness of MUC1 vaccination in combination with drugs known to inhibit immunosuppression to determine which drug is the most effective. Methods: Mice that are transgenic for human MUC1 (MUC1.Tg) mice were orthotopically injected with a syngenic breast cancer cell line expressing human MUC1 (Mtag.MUC1). Mice were vaccinated after palpable tumor formation with the vaccine cocktail, consisting of two MHC class I-restricted MUC1 tandem repeat peptides and a class II pan helper peptide mixed with GM-CSF and CpG ODN, in incomplete Freund s adjuvant. Previous work in our lab has shown that blocking the cyclooxygenase pathway (COX) resulted in an inhibition of immunosuppression. Thus we used the following drugs in combination with the MUC1-vaccine therapy: Indomethacin (COX1 and COX2 inhibitor), Celecoxib (COX2 inhibitor), 1-methyl tryptophan (indoleamine 2,3 dioxygenase inihibitor), and AH6809 (EP2 receptor antagonist). Mice were euthanized and tissue was collected post the final vaccination.

关键词：乳腺癌；糖蛋白；免疫抑制；转移；医药

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As of May 6, 2013, Michigan had reported 167 (52%) of the 320 paraspinal or spinal infections without meningitis associated with the 20122013 fungal meningitis outbreak nationally. Although the index patient (1) had a laboratory-confirmed Aspergillus fumigatus infection, the fungus most often identified, including in unopened vials of methylprednisolone acetate (MPA), remains Exserohilum rostratum, a common black mold found on plants and in soil (2). Exposures have occurred through epidural, paraspinal, peripheral nerve, and intra-articular injection with MPA from contaminated lots compounded by the New England Compounding Center in Framingham, Massachusetts. The Michigan Department of Community Health and CDC conducted case ascertainment to describe epidemiologic and clinical characteristics of Michigan patients and to determine factors that might have contributed to the high percentage of spinal and paraspinal infections reported from Michigan. A distinct epidemiologic or clinical difference was not observed between patients with paraspinal or spinal infection with and without meningitis. Lengthy periods (range: 12121 days) were observed from date of last injection with contaminated MPA to date of first magnetic resonance imaging (MRI) finding indicative of infection. Clinicians should continue to maintain a higher index of suspicion for patients who received injections with contaminated MPA but have not developed infection.

关键词：发病率；死亡率；脊柱感染；医药

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