Antisense and RNAi therapeutics are new innovative therapeutic options that can be used for the treatment of serious chronic and rare diseases. RNAi is an RNA-based gene silencing process in which RNA molecules inhibit gene expression by destroying specific mRNA molecules. Antisense technology involves the synthesis of a strand of nucleic acid that would bind to the disease-causing mRNA. It binds to the mRNA or to a splicing site on the pre-mRNA and inactivates it effectively. RNAi and antisense are two of the predominant technologies used by pharmaceutical companies, research institutes, and others for various applications in research, diagnostics, and therapeutics. RNAi therapeutics offers a wide scope in the treatment of diseases such as cancer and neurodegenerative diseases. Two types of RNA molecules are used in RNAi technology: miRNA and siRNA. RNAi molecules bind to other specific RNAs in the cell, such as mRNA, to manage their activity to treat the RNA-mediated disorder.

关键词：反义；RNAi疗法；创新；治疗选择；慢性疾病；罕见疾病

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Geomembranes are synthetic membrane liners used in geotechnical engineering to contain or control the flow of fluids or vapors. The two common processes used to manufactur geomembranes are calendering and extrusion; the raw materials used are polyethylene bitumen composites, or geotextiles in combination with polymer sprays, colorants, asphalt, or elastomers. HDPE, LDPE, PVC, PP, and EPDM are the most widely used forms. Geomembranes are vital to the Waste Management, Water Management, and Mining industries.

关键词：土工膜；岩土工程合成膜；控制流体；蒸汽；流动

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miRNAs are single-stranded, small, non-coding RNA molecules that regulate gene expression at the translation level. They play a vital role in research, diagnostics, and therapeutics to study expression of genes and to control diseases by gene silencing. They interact with mRNA molecules and regulate expression of genes by mRNA cleavage, translational repression, and deadenylation. They are generally 17-27 nucleotides long and regulate post-transcriptional mRNA expression by binding to the 3’ untranslated region of the mRNA sequence, which results in translational suppression and gene silencing. miRNAs are involved in a wide range of biological processes, including apoptosis, cell cycle control, and several developmental processes such as stem cell differentiation, hypoxia, hematopoiesis, neurogenesis, insulin secretion, cardiac and skeletal muscle development, aging, cholesterol metabolism, viral replication, and immune responses. They can be used as therapeutics for the treatment of some severe diseases including cancer and genetic disorders by introducing specific miRNAs into diseased cells to silence the defective gene.

关键词：miRNA；单链；非编码RNA分子；调节；基因表达；研究；诊断；治疗

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Mini excavators, commonly known as compact excavators, are tracked or wheeled vehicles. They weigh approximately 0.7 to 8.5 tons, and are unique compared to other excavators. Due to their small size, mini excavators can fit through doorways and can be used to carry out work at mining sites. Also, mini excavators can be easily craned anywhere or can be transported by an average truck with a trailer hitch. Mini excavators come with huge benefits. One of the major benefits of the equipment is its easy transportation from one site to another. In addition, it has various other attachments that can be used for drilling holes, digging trenches, and breaking rock.

关键词：小型挖掘机；跟踪；执行工作；采矿点；便捷的交通；钻孔；挖沟槽

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Elevators are a type of transport system that facilitate the vertical transit of people and goods within a building's premises. Escalators are moving staircases that are mainly used for transporting people between the different floors of buildings. People depend on elevators and escalators in various places such as airports, office buildings, malls, residential complexes, schools, and railway stations.

关键词：电梯；运输系统；中转垂直；自动扶梯

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A truck is a vehicle used to transport materials and other goods from one place to another. The various categories of trucks include light duty trucks, medium duty trucks, and heavy duty trucks. Heavy duty trucks are trucks that have a GVWR greater than 26,000 lb and are usually used for performing heavy duty work such as heavy duty loading/pick-up and concrete mixer applications used in construction.

关键词：卡车；运输材料；轻型卡车；中型卡车；重型卡

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The Food industry is the largest of all industries in the world and plays an important role in the economy of any country. The Global Food and Beverages market is expected to reach US$5.77 trillion by 2017, growing at a CAGR of 5.02 percent. Since food products need to reach the customers in fresh form, they require extremely protective and durable materials for packaging. An increase in the demand for prepared food and dairy products has brought a transformation in the Packaging industry. The vendors in the Global Food Packaging market are continuously inventing new packaging materials that can prevent contamination of food products. Some food packaging types are cups, cans, sachets, bottles, and tubs, which are made for the convenience of the customer and the requirement of the product. Apart from providing convenience to the customers, packaging plays a major role in attracting the customers to purchase the product.

关键词：食品行业；全球食品；饮料市场；新鲜形式

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Fabry disease is an inheritable lysosomal storage disease characterized by excessive accumulation of GL-3 in lysosomes. It results from the deficiency of α-Gal and can result in symptoms such as fatigue, angiokeratoma, tinnitus, kidney failure, heart disorders and anervous system problems. Fabry disease results from mutations in the GLA gene resulting in decreased activity or complete absence of α-Gal.

关键词：法布里病；遗传溶酶体；贮积病；过度；GL-3

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Savory snacks are salty snacks made from natural as well as artificial ingredients. It includes potato chips, extruded snacks, nuts and seeds, traditional snacks, popcorn, pretzels, meat snacks, and other savory snacks.

关键词：咸味零食；自然；人工原料

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Fungicides are a class of pesticide that are formulated to inhibit or kill the growth of fungus on crops and plants. Fungicides that are synthesized from natural sources are commonly known as bio-fungicides. An increase in the global demand for food has increased the pressure on farmers to enhance their crop yield. Hence, farmers are increasingly adopting fungicides to meet the demand for food. The major types of fungicide used include triazoles, strobilurins, dithiocarbamates, inorganics, other azoles, phthalimides, and benzimidazoles. Fungicides are also used for non-crop applications such as turf and ornamental management.

关键词：杀真菌剂；农药；天然来源合成；生物杀菌剂；提高；作物产量

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