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辅陪伴分子、芯片在非依赖性雄激素前列腺肿瘤中的作用

Role of the Co-Chaperone, CHIP, in Androgen-Independent Prostate Cancer
作者:Phillips, C. K. 作者单位:Mount Sinai School of Medicine, New York. 加工时间:2014-09-17 信息来源:科技报告(AD) 索取原文[23 页]
关键词:前列腺癌雄激素;基因治疗;;化疗;芯片(电子);缺陷(材料)
摘 要:Androgen ablation, or androgen deprivation therapy (ADT), is the mainstay of treatment for patients with locally advanced or metastatic prostate cancer. This therapy is only temporizing, however. Within 3-4 years, the vast majority of patients develop androgen independent prostate cancer (AIPC). Though several new treatments have recently been approved, once a patient develops AIPC, options are less effective, with first line chemotherapy providing only 13-15 month survival.(1) The shift from androgen sensitive prostate cancer (ASPC) to AIPC is a seminal event in disease progression and thus it has been extensively studied. At the center of much of this research is the androgen receptor since many believe that the overexpression, mutation and/or constitutive activation of this receptor play a critical role in the progression from ASPC to AIPC. The chaperone proteins heat shock protein-90 (Hsp90) and Hsp40 are necessary for the correct formation of AR s tertiary structure. Subsequently a second co-chaperone, Cterminal Hsp interacting protein (CHIP), was characterized and found to bind HSP 70 and 90. CHIP contains E3 ligase activity which targets proteins for proteosomal ubiquitination and can also directly bind to a highly conserved portion of AR which increases degradation. In cells where CHIP is overexpressed, AR synthesis is decreased and much of the AR produced has a defective tertiary structure which prevents degradation. The addition of proteosomal inhibitors to the cells, does not restore AR levels to normal, indicating that AR degradation/suppression is occurring by non-proteosomal pathway(s) as well. The role of this study is to better characterize the interaction of CHIP and the androgen receptor and assess its role in disease progression.
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