关键词：纳米粒子；磁共振成像；生物医学
摘 要：One of the most rapidly growing and exciting applications of nanotechnology in biomedical research is the development of biocompatible magnetic nanoparticles (NPs) for use in powerful and highly complementary bio-imaging modalities. Biocompatible magnetic NPs should be effective as contrast agents (CAs) in magnetic resonance imaging (MRI), and the unique physical properties of magnetic NPs as well as their conjugation with dyes and/or radioactive elements could lead to the development of the multimodal bio-imaging probes for use in MRI/optical imaging, PET/MRI, and MRI/optical/therapy. Multimodal bio-imaging is quite attractive for the early and precise diagnosis of disease, leading to theranostics, since it combines the advantages of, and provides complementary information from, several imaging modalities. The metabolism of magnetic NPs strongly depends on their size, but also on individual surface characteristics, like charge, morphology and surface chemistry. Accordingly, the creation of novel magnetic NPs for multimodal bio-imaging can be realized only with the fusion of multiple disciplines, including chemistry, material science, biology, and engineering. In this chapter, recent advances in the use of magnetic NPs, represented by iron oxide NPs, manganese oxide NPs, and gadolinium oxide NPs, for multimodal bio-imaging are highlighted and summarized.