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奈米流体与太赫兹光谱系统集成平台的生物传感器的发展

Development of a Biosensor Nanofluidic Platform for Integration with Terahertz Spectroscopic System

作者:Globus, T.; Moyer, A.; Ferrance, J.; Sizov, I.; Khromova, T. 作者单位:Army Research Office, Research Triangle Park, NC. 加工时间:2015-09-09 信息来源:科技报告(AD) 索取原文[13 页]
关键词:芯片;光谱系统;生物传感器
摘 要:A modified configuration for a THz stage has been designed, fabricated and assembled with the final goal to combine the THz spectrometer with a microfluidic platform for characterization of biological samples in solutions. The new stage accommodates a modified optical mounting system that focuses THz radiation on micro/nanofluidic chips with reduced size of 1.5 mm x 3.0 mm for the active region, encompassing 10 sample channels in parallel. Another important improvement to the stage is modified linear positioning of the microdetector with a probe relative to the microfluidic chip in a near field configuration. A significant change in the software for computer controlled operation has also been made. We continued protocol development for spectroscopic characterization of biomaterials using micro/nanofluidic chips. The algorithm for amplitude and frequency shift corrections has been investigated and tested. The possibility to further improve spectral resolution has been demonstrated.
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