关键词：PHA；生物医学研究；手术缝合线
摘 要：The chapter describes research of biomedical applications of experimental polymer devices prepared from polyhydroxyalkanoates (PHAs) with different chemical structure in the Institute of Biophysics SB RAS and Siberian Federal University (Krasnoyarsk, Russia) between 2000 and 2012. The high-purity PHA specimens were investigated and then used to prepare surgical sutures, 2D and 3D dense and porous matrices, microparticles, monofilament fibers, fully resorbable tubular stents, and polymer coatings. The polymer devices that differed in their shape and mass were introduced into muscles, bones, blood vessels, and internal organs in order to investigate the response of tissues with different structure to the implants. The studies showed that PHAs were highly biocompatible with different tissues and their implantation for extended periods of time did not induce adverse responses of the blood system, cells, tissues, or the entire organism. The authors proved that PHAs can be effectively used as prosthetic implants, suture material, bone-replacing implants, and matrices for drug delivery.
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