关键词：细胞培养;组织(生物学);器官;生物再生;临床医学;体内分析
摘 要：The proposed work aims to address three major challenges to the field of regenerative medicine: (1) the growth and expansion of regenerative cells outside the body in controlled in vitro environments, (2) supportive vascular supply for large tissue engineered constructs, and (3) interactive biomaterials that can orchestrate tissue development in vivo. Toward this goal, we have engaged a team of scientists with expertise in cell and molecular biology, physiology, biomaterials, controlled release, nanomaterials, tissue engineering, bioengineering, and clinical medicine to address all three challenges. This combination of resources, combined with the vast infrastructure of the WFIRM, have brought to bear on projects to discover and test new sources of autologous cells that can be used therapeutically, novel methods to improve vascular support for engineered tissues in vivo, and to develop intelligent biomaterials and bioreactor systems that interact favorably with stem and progenitor cells to drive tissue maturation.