关键词：血液凝固；出血；血液循环；医药
摘 要：Hemorrhage is a leading cause of deaths on the battlefield. An understanding of the mechanisms and modulators of coagulopathy under conditions soldiers currently experience on the battlefield is important for improved treatment of the hemorrhaging soldier. The global objective of this project tests the hypothesis that environmental and physiological conditions a soldier experiences on the battlefield alters hemodynamic and hemostatic function (i.e., coagulation and fibrinolysis). During the current funding period, we sought to obtain the required IRB and ORP approvals, acquire the necessary equipment to accomplish the stated aims, and complete the objectives in specific aim 1. Aim 1 tests the hypothesis that passive heat stress alters hemostatic function during simulated hemorrhage. ORP documents were submitted for initial administrative review April 4, 2012 and final approval was granted October 10, 2012. Data collection began November 7, 2012. Each subject completes a normothermic and heat stress trial (both including a hemorrhagic challenge), separated by at least 60 days (owing to the amount of blood drawn for each trial). 10 subjects have completed both trials, with the final 2 subjects completing their second trial this May. Data from blood based assays of hemostatic function are presently being processed, while plasma-based assays are expected to be run by Dr. Cap s laboratory at the US Army Institute of Surgical Research by August 2013.