关键词：医药；治疗技术；血管疾病；淋巴系统
摘 要：In the current funding period, we completed studies on the protective effects of adenoviral induced VEGF-D and compared this effect to VEGF-C. These findings were correlated with lymphatic and blood vessel density and support our hypothesis that lymphatic vessel induction is protective in IBD. These findings support lymphatic expansion as a controlling element of blood vessel expansion. We next examined the effects of VEGFR-2 kinase inhibitor, SU1498 and a VEGFR-2 competitor antibody on acute erosive colitis. VEGFR-2 blockade was protective in some phases of colitis and appears to reflect suppression of blood vessels. We also explored whether and how blockade of the pro-lymphangiogenic VEGF receptor, VEGFR-3 (using MAZ51, a VEGFR-3 kinase blocker) would affect acute erosive colitis. We found that VEGFR-3 blockade lead to significant increases in gut tissue injury, particularly when given during the recovery phase of the DSS model. This suggests to us that lymphatics may exert protective influences colitis by hastening recovery from disease rather than preventing its induction.