关键词：生物质能；纤维素；乙醇；生物质转化；分子动力学；仿真；木质纤维素生物质
摘 要：A CHARMM molecular mechanics force field for lignin is derived. Parameteriza- tion is based on reproducing quantum mechanical data of model compounds. Partial atomic charges are derived by the examination of methoxybenzene: water interactions. Dihedral parameters are optimized by fitting to critical rotational potentials, and bonded parameters are obtained by optimizing vibrational frequencies and normal modes. The force field is validated by performing a molecular dynamics simulation of a crystal of a lignin fragment molecule and comparing simulation-derived structural features with experimental results. Together with the existing force field for polysaccharides, this work will enable full simulations of lignocellulose.