关键词：听觉缺陷；药物；治疗；爆炸
摘 要：The goal of this research was to compare, in the rescue mode of treatment, the effectiveness of (1) L-N-acetylcysteine (L-NAC); (2) D- Methionine (D-MET); (3) Ebselen SPI-1005; (4) Acetyl-L-carnitine (ALCAR) and (5) Src-PTK inhibitor, KX1-004 in reducing hearing and sensory cell loss as the result of an acute acoustic trauma that simulates blast injury to the auditory system. A shock tube was used to produce a blast injury to the cochlea in a chinchilla model. A secondary goal was to apply the same drug administration protocol to groups of animals exposed to a lower level continuous noise. Data from the treated and control animals consisted of: (1) auditory evoked potential hearing thresholds; (2) cubic distortion product otoacoustic emissions (DPOAE) input/output functions along with DPOAEs as a function of frequency (DPEgram) to estimate sensory cell function; (3) tympanograms to screen for conductive changes; (4) surface preparation histology to estimate the frequency specific sensory cell loss. Statistical analysis of the data employed a mixed model analyses of variance with repeated measures on one factor (frequency) using the SPSS Release 4.0 statistical package. Results: (1) There were no statistically significant differences between drug treated groups and controls. (2) There was a very large inter subject variability for all exposure groups.