关键词：支气管灌洗液;清洁;临床医学疾病,尘埃,尘埃滴注法;接触(生理学);肺癌;肺损伤;微rna生物标志物;病理学;蛋白生物标志物;蛋白质;肺功能;大鼠;二氧化硅;创伤和损伤
摘 要：To understand the risks of lung disease faced by soldiers, USACEHR has studied a rat model of lung disease after instillation of dust or silica. After exposure, lung pathology was measured and we identified the proteins and microRNAs that were released into the lung lavage fluid at different times after exposure so that the markers could be correlated with the observed pathology. In this model silica affected the lung more than dust from Iraq, and we reported the proteins and microRNAs we found in lavage fluid after either treatment. The candidate biomarkers we found came from lavage fluid which is relatively accessible. The markers we found can now be compared to markers from human clinical specimens. This work is underway via a collaboration with the STAMPEDE project at BAMC.