关键词：基因调控网络；数学建模；参数辨识
摘 要：In mathematical modeling of genetic regulation networks, the classical assumption is that the direction of regulation by a regulator (activation or repression) on a specific target gene is fixed. However experimental studies have suggested that the direction of gene regulation might be concentration-dependent. Earlier modeling work assumed only specific transcription factors behave in this concentration-dependent manner. Nevertheless, based on our in vivo DNA occupancy measurements of transcription factors and target gene mRNA expressions, we propose that concentration-dependent activation or repression might be a more general phenomenon.