关键词：临床医学;连续性;药;免疫治疗;淋巴结;测试与评估
摘 要：The goal of this project is to engineer T-cells for adoptive cell therapy of prostate cancer, by conjugating drug-loaded nanoparticles to therapeutic cells to enable targeted drug delivery to tumor sites and lymph nodes. Nanoparticles with cytokine proteins bound to their surfaces will be attached to the surface of T-cells the equivalent of delivering a drug-loaded pill to each individual anti-tumor T-cell. These drug-carrying T-Pharmacytes will be continuously stimulated by the protein and carry these cytokine-loaded particles wherever they traffic in the body. We hypothesize that this strategy will provide a safe and effective means to augment adoptive cell therapy and allow the great promise of this immunotherapy to be realized for treatment of prostate cancer. The proposed studies will provide a preclinical test of this concept. If successful, this approach to enhancing an immunotherapy strategy already in clinical trials might be translated to patient treatment in a relatively short timespan.