关键词：人类免疫缺陷病毒;抗体;背景;临床医学;咨询;死亡;血红蛋白
摘 要：Background: Although highly active antiretroviral therapy (HAART) has improved HIV survival, some patients receiving therapy are still dying. This analysis was conducted to identify factors associated with increased risk of post-HAART mortality. Methods: We evaluated baseline (prior to HAART initiation) clinical, demographic and laboratory factors (including CD4+ count and HIV RNA level) for associations with subsequent mortality in 1,600 patients who began HAART in a prospective observational cohort of HIV-infected U.S. military personnel. Results: Cumulative mortality was 5, 10and 18at 4, 8 and 12 years post-HAART. Mortality was highest (6.23 deaths/100 person-years PY) in those with 8804;50 CD4+ cells/mm3 before HAART initiation, and became progressively lower as CD4+ counts increased (0.70/100 PY with 8805; 500 CD4+ cells/mm3).