Molecular Mechanisms Underlying Genomic Instability in Brca-Deficient Cells
作者:Nussenzweig, A. 加工时间:2015-08-05 信息来源:科技报告(AD) 索取原文[56 页]
关键词:乳腺癌细胞(生物学);基因组;不稳定性 摘 要:Our proposal is to explore the novel notion that it may be possible to restore near normal HR activity in Brca1 cells and tissues. We believe that this phenomenon will lead to targeted therapies to reduce lifetime risk of tumor formation in BRCA1 and potentially BRCA2 carriers.