关键词：血压；伯恩斯（伤害）；临床医学；闭环系统；决策支持系统
摘 要：Trauma, hemorrhage and burns leads to hypovolemia and hypovolemic shock. Fluid therapy restores normalcy in physiological endpoints, such as cardiac output and blood pressure, but can result in secondary insults, such as excessive edema, if not titrated well. Fluid therapy is labor intensive and requires significant attention by caregivers, who can be overwhelmed in a mass casualty situation. Closed loop fluid resuscitation systems hold great potential to optimize fluid therapy with fewer secondary insults, respond more quickly to changes in patient condition, automate caregiver tasks, reduce variability in care due to fatigue or inexperience and be a force multiplier in mass casualty situations. In this project we have iteratively developed a closed loop fluid delivery system (CLFDS) and conducted a human hemorrhage model clinical study. Clinical data indicates the CLFDS maintains target blood pressure with less fluid and extravascular fluid than the standard of care approach.