关键词：乳腺癌；化疗；超声；算法；血管生成
摘 要：Neoadjuvant chemotherapy is currently the standard of care for locally advanced breast cancer (LABC). Monitoring tumor response is advantageous for patients. This project aims to using the subharmonic signals from ultrasound contrast agents to improve the monitoring of breast cancer treatment response to neoadjuvant therapies in women diagnosed with LABC by imaging tumor angiogenesis with 3D subharmonic imaging (SHI) and by estimating the interstitial fluid pressure (IFP) using 3D subharmonic aided pressure estimation (SHAPE). To date, software for analyzing RF data from a Logiq 9 ultrasound scanner (GE Healthcare, Milwauke, WI) to produce 3D SHAPE pressure estimates has been successfully developed. Initial in vivo experiments in 2 canines have been completed. SHI and the optimization algorithm implemented indicate that the use of SHAPE for noninvasive evaluation of the IFP in breast lesions is feasible with Definity. Moreover, However, difficulty in obtaining the necessary approvals for our human clinical trial has delayed the project by approximately 8 months.