关键词：类肽薄膜；生物传感器；潜在使用；医疗器械；生物电子；生物分子识别
摘 要：Peptoids are biomimetic polymers that combine the properties of proteins and plastics. This class of materials is predicted to play a significant role in several bio-electronic applications such as biosensors, drug discovery, and biomolecular recognition. In order to realize such potential, films of peptoids must first be reliably produced or transferred onto substrates of interest. This work reports the production of thin films of peptoids by way of various methods, including Gibbs monolayers, Layerby- Layer multilayers, and peptoid nanosheet (bilayer) formation. Gibbs films were successfully transferred onto silanized silicon substrates using the Langmuir-Schaefer technique as verified by X-ray Photoelectron Spectroscopy and Atomic Force Microscopy. Gibbs films were also prepared from a peptoid-peptide hybrid polymer, containing a peptide sequence specifically recognized and phosphorylated by the enzyme Casein Kinase II (CK2). An Ion-Sensitive Field-Effect Transistor containing this peptoid-peptide hybrid film is being fabricated as a biosensor for detecting CK2 activity.