关键词：医疗服务；创伤后应激障碍；响应（生物学）
摘 要：Although selective serotonin reuptake inhibitors (SSRIs) are routinely prescribed for acute stress disorder and early PTSD and recommended in the VA-DoD best practice guidelines, the efficacy of SSRIs as an early intervention for PTSD in service members returning from war-zone duty has still not been determined. Consequently, this study was designed to conduct a controlled trial of fluoxetine as an early intervention for recently redeployed soldiers, as well as to develop methodologies for understanding the multiple factors that may predict outcome. The study was conducted at two sites: Carl R. Darnall Army Medical Center and Central Texas Veterans Health Care System. Despite recruitment efforts, only 42 participants were enrolled. Of these, 18 were randomized. The limited enrollment obscures interpretation of the results. No unexpected side effects were observed. Our data does not support or refute the use of SSRIs for treatment of PTSD.