关键词：神经；再生（生理学）；修复；医药
摘 要：The primary goal of this collaborative research project is to develop next generation engineered nerve guide conduits (NGCs) with aligned nanofibers and favorable release kinetics of neurotrophic factors to help improve surgical outcomes after injuries involving peripheral nerves. In the second year of the work, we further improved the gradient loading of the neurotrophic factor GDNF (Glial cell derived neurotrophic factor) and tested various combinations of NGCs in a rat sciatic nerve regeneration model. We have also started the IACUC application for the large animal validation study using the peroneal nerve repair in dogs.