关键词：血液中的血小板；血管内的血块；刺激（生理）；医药
摘 要：Hemostasis is arguably the highest treatment priority for the polytraumatized patient. Best hemostasis practices cannot be developed if we lack a more full understanding of the cell-based clotting system during trauma. In order to address this fundamental knowledge gap, this study will provide a comprehensive characterization of the most important cellular component of the coagulation system, the platelet. The study proposes a comprehensive characterization of platelet function over time in civilian victims of polytrauma that may inform development of new diagnostic, therapeutic, and clinical guidelines for hemorrhage control and treatment of coagulopathy in trauma. We have successfully developed a comprehensive panel of tests to include: 1. Platelet aggregation by aggregometry under conditions of low and high shear stress and in response to collagen and ADP stimulation, 2. Platelet- associated thrombin generation using calibrated automated thrombography, 3. Platelet-induced clot contraction and using viscoelastic measures such as TEG with Platelet Mapping and, 4. Flow cytometry for platelet receptor and white cell activation as well as circulating platelet and platelet-monocyte aggregates. These panels are being coupled with a comprehensive data base of trauma victim demographics, diagnostics, and therapeutics to define the relationships between platelet function and injury pattern/severity, tissue hypoperfusion, transfusion, traumatic brain injury, inflammation, and clinical outcomes.