用于超声成像和转移性前列腺癌病变消融的纳米气泡的研制
Development of Targeted Nanobubbles for Ultrasound Imaging and Ablation of Metastatic Prostate Cancer Lesions
关键词:前列腺癌;烧蚀;气泡;空化
摘 要:We report the synthesis of the amphiphilic PEG-b (PAA)-b-P(HDFMA-co- MMA) copolymers that proved to encapsulate 1%-2% v/v PFP forming nanodroplets. Combining these nanodroplets with histotripsy proved to generate a cavitation bubble cloud with similar behavior but lower pressure compared to histotripsy itself. Moreover, these nanodroplets maintained their average size and concentration upon incubation with BSA for 24 hours at 37 degrees celcius, which prove their promise for cancer cell ablation and warrant their future testing in vivo.