关键词：卵巢癌的细胞（生物学）；生长（生理学）；炎症；医药
摘 要：During the research period, we have successfully achieved our goals of demonstrating IL6R in the ovarian tumor microenvironment and identifying the differentially-spliced isoform as being prominent. In addition, we have demonstrated an important relationship between IL6R expression and the earliest steps in metastasis of ovarian cancer. Both tumor cells and host myeloid cells contribute to IL6R expression within a tumor, thus providing multiple targets for intervening in ovarian cancer metastasis. Our continuing studies will identify the mechanism by which IL6R influences metastasis and opportunities for preventing or reducing this outcome.