关键词：大气；空气质量；免疫
摘 要：The objective of this study was to determine the impact of early life episodic ozone and particulate matter (PM) exposure on parameters of immunity that affect responses to infectious disease and lung function. We investigated a cohort of 50 California National Primate Research Center (CNPRC) outdoor colony rhesus monkeys that were born within three months prior to the Trinity and Humboldt County wildfires of June/July 2008. We hypothesized that combined ozone and wildfire PM(sub 2.5) exposure during early life would result in detrimental effects on immunity and lung physiology. To test this hypothesis, we conducted a nonterminal and minimally invasive study in three-year old adolescent monkeys exposed to combined ozone and wildfire PM(sub 2.5) as infants by (1) evaluation of the peripheral blood response to microbial ligands and (2) measurement of lung mechanics. Compared with a cohort of 50 age-matched control monkeys, peripheral blood cells from exposed animals showed reduced cytokine synthesis when cultured with microbial ligands. Increased airways hyperresponsiveness and reduced lung compliance correlated with reduced peripheral blood cell cytokine synthesis in exposed female animals (less response to microbial challenge). We conclude that early life exposure to combined ozone and wildfire PM(sub 2.5) can result in immune and lung function decrements that persist with maturity. In addition, CNPRC rhesus monkeys could serve as biologic sentinels for chronic human health effects of ambient air pollution.