最新进展和合成无机Glyconanoparticles应用作为生物治疗和诊断试剂
Recent Advance in Synthesis and Application of Inorganic Glyconanoparticles as Bio-therapeutics and Diagnostics agents
关键词:无机纳米药;金属纳米粒子;碳水化合物;生物医学
摘 要:Carbohydrates are attractive molecules for drug discovery because sugars are involved in many intricate human diseases including cancer and infectious diseases. Potential therapeutic and diagnostic benefits of sugar-based drugs, however, are offset by the poor pharmacologic properties of these molecules that include speedy serum clearance, poor cellular uptake, and the relatively high concentrations required for efficacy. To address these issues, carbohydrates are functionalized with nano carrier as similar to peptides, proteins and DNA. Considering the vast relevance of Inorganic nanoparticles as promising candidates for electronic, optical, magnetic and biomedical applications, several metals linked glyconanoparticles (GNPs) are synthesized and applied for biomedical application. This article will elaborately discuss about the progress in the development of metallic GNPs for various biological applications as drug candidates and detection agents.