关键词：诊断（医学）;乳腺癌;疾病;乳腺腺体
摘 要：Ductal carcinoma in situ (DCIS) makes up 18of all new breast cancer diagnoses, and is considered a precursor to invasive breast cancer even though the majority of cases almost 70may never progress to invasive disease. Markers that identify which patients are most likely to experience progression are critically needed so that fewer patients are over-treated. This study is evaluating two novel tumor markers that may indicate greater risk of tumor progression based on recent work that suggests that stromal syndecan-1 expression induces an extracellular matrix with aligned collagen fiber architecture, and that this collagen alignment in turn facilitates malignant cell invasion. We are using archived tumor tissue from 267 cases of DCIS of the breast to evaluate syndecan-1 expression and collagen alignment. These DCIS cases, diagnosed between 1995 and 1999, have been followed for breast cancer outcomes; to-date, 13of cases have experienced a second breast cancer diagnosis. Analysis of syndecan-1 expression and collagen alignment patterns will be completed soon, and preliminary data analysis has begun. Findings from this research are expected to be disseminated through peer-reviewed journals and for presentation at national conferences by the end of the year.