关键词：单分子膜；复合材料；磷酸钙
摘 要：Poly(hydroxyalkanoates), PHAs, are biologically-derived polyesters with fascinating properties. Produced controllably and sustainably during biosynthesis, they can be considered as potential replacements of petroleum-derived plastics in applications ranging from packaging to biomedical materials. The possibilities to chemically functionalize PHAs offer an avenue to include in PHA materials features such as polarity or reactivity, tailored towards specific applications. Particular interest in PHAs stems from their biocompatibility and degradability, relevant not only for biomaterials behavior but also considering the polymer lifecycle and waste management. In the medical field, PHAs have been considered for drug delivery, wound management, implants for the cardiovascular system and orthopedic materials in bone tissue engineering to produce bone graft substitutes, scaffolds for bone and cartilage repair, spinal cages or internal fixation devices (screws). In this chapter, we will first briefly review some successful applications of PHAs in this area. The second part will be devoted to orthopedic applications (e.g. to improve biocompatibility of implant coatings), including attempts to gain more fundamental understanding on how to control PHA interfaces to optimize the nucleation and growth of calcium phosphate, the main bone mineral.