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耐辐射碳离子光束的诱变效应

Mutagenic Effect of Carbon Ion Beams in Deinococcus radiodurans

作者:K. Satoh;T. Onodera;K. Takeda;I. Narumi 作者单位:Medical and Biotechnological Application Division, QuBS, JAEA;Medical and Biotechnological Application Division, QuBS, JAEA,Graduate School of Life Sciences 加工时间:2015-09-02 信息来源:科技报告(Other) 索取原文[1 页]
关键词:电池寿命;碳离子光束;电池性能
摘 要:Ionizing radiation induces DNA double-strand breaks (DSBs), which is a particularly serious form of DNA damage and has especially deleterious effects in cells. Ion beams have high linear energy transfer (LET, keV/μm) and give DNA damage containing DSBs locally (clustered damage) than gamma rays do. Deinococcus radiodurans exhibits extraordinary resistance to the lethal effects of ionizing radiations. This resistance has been attributed to its highly proficient DNA repair capacity. Previously, it had been reported that the DNA repair mechanism of D. radiodurans is not necessarily "error-free" since there were an increase in rifampicin-resistant mutant frequency depending on radiation doses of ion beams and gamma rays. In this study, we investigated mutant frequencies of two different antibiotic-resistant mutants for carbon ion beams in D. radiodurans and identified the mutation sites in the antibiotic-resistant mutants.
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