关键词：基因组；蛋白质；纳米线
摘 要：The development of genome and proteomic technologies is related, first of all, to the progress recently achieved in developing of high-sensitivity, rapid methods for registration and analysis of nucleic acids and proteins. One of such methods, combining high sensitivity and high response speed, is the nanowire (NW) detection technique. This technique allows one to register analyte species in real time without using labels. Nowadays, the concentration sensitivity of such systems in registering proteins and DNAs reaches the femtomolar level. In the present chapter, we consider nanowire sensor systems based on silicon nanowire field-effect transistors. We discuss the achieved potential in detecting low-copy proteins with the help of nanowire systems. We show that it is possible to use not only antibodies, but also aptamers, as probing molecules for biospecific protein detection. We also discuss the possibility of using nanowire detectors in genome studies.