关键词：低于大气压压力处理；伤性脑损伤；创伤和损伤；大脑皮质
摘 要：Each major war tends to have a signature injury , with traumatic brain injury (TBI) associated with the Iraq war (Operation Iraqi Freedom II and Operation Enduring Freedom) due to the high incidence of personnel injured by IED (improvised explosive devices). Our previous study in a rat model showed that Mechanical Tissue Resuscitation (MTR the controlled application of vacuum) to the cerebral cortex following a controlled cortical impact (CCI) injury reduces brain edema and the extent of injury, modulates metabolites in injured neuronal tissues, preserves neuronal tissue, and improves functional recovery. The large gyrencephalic brain of swine is similar to humans, thus a swine model of CCI injury and MTR treatment was evaluated for future human clinical applications. Year 1 goals were to determine the level of vacuum which resulted in the most efficacious result. Year 2 goals were to determine the length of time that the 100 mm Hg of applied sub-atmospheric pressure (determined in Year 1) was necessary to prevent late cell injury and death and late increase in intracranial pressure. Year 3 goals were to determine the length of delay between creation of the injury and application of the localized vacuum to the site of injury to prevent or minimize the size and progression of the injury.