关键词：恐惧；内存；老鼠；脑细胞（生物学）
摘 要：The purpose of the report is to determine in a mouse model of high and low fear whether a protein expressed in the lateral amygdala is more abundance in the high fear mice following Pavlovian fear conditioning. These data provide important insights into the micro network mechanisms in the barin that may lead to different levels of fear response in individuals. Understanding the circuit level cellular and molecular mechanisms that underlie individual variability in far learning is critical for the development of effective treatment of fear-related illnesses such as PTSD. These data suggest that inhibiting a specific protein in a precise brain region in mice may reduce high fear memory to the level of low fear memory. This information may begin to provide foundations for the understanding and eventual treatment of pathological fear. Using a mouse model of very high and very low fear memory to understand cellular mechanisms in specific brain regions involved in forming fear memories may help identify novel ways to predict individuals at risk for fear related illness. This can potentially lead to targeted treatments for fear-related disorders such as PTSD.