胶质生长因子2(GGF2)在脊髓损伤模型和兽医临床设置中的平移的药理药效研究
Translational Pharmacologic Efficacy Studies of Glial Growth Factor 2 (GGF2) in Spinal Cord Injury Models and in the Veterinary Clinical Setting
关键词:临床医学;组织病理学;神经纤维;鞘(解剖);脊髓;兽药;创伤和损伤
摘 要:The goals of our studies in year 2 were to (a) use the most effective dosages and route of administration of GGF2 on the proliferation of NG2-expressing glia cells after SCI that we identified in year 1 in long term studies of effects on functional recovery and chronic histopathology and (b) subject spinal cords from some of these rats to MRI and Diffusion Tensor Imaging (DTI) of the spinal cord to develop MRI imaging method that can detect treatment effects that improve survival and myelination of axons after SCI for potential use in future dog studies.