关键词：乳腺癌;氯喹;体内分析;大鼠;风险;化学预防
摘 要：This translational epidemiologic study conducted online aims to confirm preclinical data on the chemopreventive potential of chloroquine (aminoquinoline), a well-characterized anti-malarial drug. Exposure to chloroquine, an off-patent anti-malarial drug with a 60-year history of use by millions, reduces the incidence of breast cancer in genetically programmed rats by 37%. About 65% of Peace Corps volunteers received chloroquine prophylactically between 1965 and 1990. Therefore, we will collect chloroquine exposure, breast cancer risk, and breast cancer diagnosis data from returned volunteers who served during this period through an online application. We will characterize participants into chloroquine exposed and unexposed groups, based on country of service and self-reported exposure status. The cost and time efficiencies afforded by this study design will allow the translation of preclinical data on breast cancer chemoprevention into public health and potentially promote the repositioning of a well-characterized and inexpensive drug.