关键词：癌；宫颈细胞；筛检；预防疾病
摘 要：Screening for cervical cancer has the potential to detect precancerous lesions and cancers in early stages, which can be effectively treated. Screening tests currently used in the United States on cervical cell samples include the Papanicolaou(Pap) test to detect cellular changes, as well as tests for high-risk human papillomavirus(HPV) genotypes. A particular challenge is the management of women with test results of atypical squamous cells of unknown significance (ASCUS) or of low-grade squamous intraepithelial lesions (LSIL) on cytology or those with a normal Pap test but a positive test for high-risk HPV genotypes, since only a fraction of these women will have a finding on colposcopically directed tissue bioposy that warrants treatment (e.g., high-grade cervical intraepithelial neoplasia (CIN)). The authors aimed to examine the role of in situ hybridization(ISH) tests, including fluorescence ISH(FISH), to detect chromosomal abnormalities or DNA from high-risk oncogenic HPV genotypes on cervical cytologic specimens to increase the clinical validity of identification of precancerous lesions or cervical cancer.