关键词：乙二醇；毒理学；癌变；呼吸系统；医药
摘 要：Toxicology and carcinogenesis studies were conducted by administering ethyleneglycol in the diet of 60 male mice (0, 6250, 12,500, or 25,000 ppm) and 60 female mice (0, 12,500, 25,000, or 50,000 ppm) for up to 103 weeks. These concentrations correspond to daily doses of approximately 1,500, 3,000, or 6,000 mg/kg body weight for male mice and 3,000, 6,000, or 12,000 mg/kg for females. Under the conditions of these 2-year feed studies, there was no evidence of carcinogenic activity of ethylene glycol in male B6C3F1 mice receiving 6,250, 12,500, or 25,000 ppm, or in female B6C3F1 mice receiving 12,500, 25,000, or 50,000 ppm. Administration of ethylene glycol resulted in hepatocellular hyaline degeneration in male mice fed diets containing 12,500 or 25,000 ppm and in female mice fed diets containing 50,000 ppm. An increased incidence of medial hyperplasia of small pulmonary arteries and arterioles occurred in female mice fed diets containing 12,500, 25,000, or 50,000 ppm ethylene glycol.