关键词：解剖模型;生物学;癌;临床医学;控制;药物;流行病学;基因;体外分析;损伤;标志;分子;肿瘤;癌病毒;卵巢癌;卵巢;患者;试验研究;前兆;制备;预防;生殖系统
摘 要：Project 1. We will determine the early molecular changes in STIC and their biological significance in developing high-grade serous carcinoma. marker selection and sample preparation will begin in the next coming months. Project 2. We will evaluate whether the presence of a STIC is associated with different clinical manifestations and/or outcome compare to those patients in whom a STIC was not identified. Molecular profiling will be initiated after quality control checking. Project 3. We will identify the early molecular changes that precede the development of STICs using gene expression analysis of morphologically normal FTE from high-risk women compared to FTE from normal control specimens and use an in vitro system and a mouse model to generate a molecularly defined carcinoma resembling HGSC from FTE and OSE using oncogenes expressed in ovarian carcinoma. Project 4 We plan to if the statin drugs are effective in preventing STIC formation and suppress tumor progression in the OVGP1 mouse model that spontaneously develops STIC and neoplasms.. Project 5. With the data and cases piling up, we will be able to address the molecular and epidemiologic profile of putative precursor lesions including STIC in the fallopian tubes and ovaries from women at high-risk for ovarian cancer. Also, a pilot study will be performed to determine the most cost-effective way to prepare the tissue sections for studies related to study early tumor development in ovarian cancer. This information will be shared with science community.