关键词：纳米生物技术；融合创新；三重螺旋模型；生物医学
摘 要：The application of nanotechnology in the field of biology has given rise to a host of innovations ranging from diagnostics, biomedical sensors, targeted drug delivery systems, to the creation of integrated chips with scalable memory. Recently, increased investments in basic nanotechnology research and demand for improved convergence based product development, have led to the organization of national innovation ecosystems such as the National Nanotechnology Initiative in the United States, National Nanotechnology Initiative and associated National Nanotechnology Centre in Malaysia and the Australia Nanotechnology Network in Australia to name a few. While academic laboratories and spin-offs have served as epicenters of nanobiotechnology commercialization across these countries, the extent of commercialization of products across developed and emerging economies is largely driven by the maturity of innovation networks and knowledge flows surrounding the nanobiotechnology initiatives. In the wake of the global market challenges of the biopharmaceuticals, successful deployment of nanobiotechnology innovations in regional economies will depend on inclusive and adaptable innovation models that can be replicated globally. To that end, this commentary discusses the design of a hybrid innovation ecosystem that captures nanotechnology policy, stakeholders, and knowledge to facilitate accelerated nanobiotechnology commercialization. Examples of innovation ecosystems in the US, Malaysia and Australia are used to demonstrate the emergence of this hybrid model where research and human capacity development including knowledge dissemination between the participating stakeholders, are the overarching goals of the designed ecosystems. Objective of Commentary: In the context of the limitations of existing innovation models as static entities that have failed to accelerate innovation and commercialization of nanotechnology innovations in medicine, an adaptable hybrid ecosystem or AHE for effective commercialization of nanomedicine and emerging technologies is proposed . The adaptable hybrid ecosystem builds upon the concepts of National Systems of Innovation, Triple Helix Model and strategic arenas-a broad area of focus that engages contributions from multidisciplinary areas. The multistakeholder participatory approach of the AHE model is suggestive of a dynamic asset pool comprising customers, industries, universities and international governments that enable technology commercialization in emerging areas such as nanomedicine and nanotechnology by the influence of fundamental paradigm shifts discussed in this paper.