关键词：癌症细胞（生物学）；基因组学；蛋白质组学
摘 要：Through this collaborative research effort, we intend to develop quantitative tools with direct applications for patients with glioblastoma. We will pursue new strategies for genome sequencing and new technologies for the genetic analyses of cancer mechanisms, as well as methods for assessment of progression and stratification of human glioblastoma. This proposal will significantly advance genomic, proteomic and single-cell technologies, and the proposed tools will be generally applicable to all cancer-based studies to identify and quantify DNA, RNAs, proteins and cells, challenges ubiquitous to all human disease systems.