关键词：腹膜透析导管腔；异物反应；新聚合物；渗透剂；糖尿病状态；腹膜硬化
摘 要：Although peritoneal dialysis was first developed in the early 20th century, there are still many challenges that need to be addressed by bioengi-neers working with nephrologists. The peritoneal dialysis catheter sets up a foreign body reaction in the cavity and often becomes infected; new polymers are needed to minimize the resulting inflammation. New osmotic agents are needed to substitute for glucose that sets up a "diabetic state" in the cavity that leads to peritoneal sclerosis. New technology that can be worn by the mobile patient and that provides continuous dialysis is an exciting development that presents significant challenges to the design engineer. Computational biology attempts to quantitatively integrate the findings in clinical studies, genomics, proteomics, metabolomics to move health care toward "personalized medicine" in order to predict outcomes and to improve care of the individual patient.