关键词：乳腺癌;正电子发射断层扫描;抗体;临床医学;检测;苷;乳腺;肿瘤;蛋白质;测试和评估;工具;生物标志物
摘 要：In this project, we focus on oxidation and glycosylation PTMs on proteins known to be secreted by the breast as candidate biomarkers for the early detection of breast cancer. ELISA microarray technology has employed to evaluate assays that have potential be used as breast cancer biomarkers. During the third year of this project we have continued the validation for our PTM- ELISA microarray. And we validated the chosen PTM antibody for pre-clinical or translational molecular imaging studies. The microPET imaging suggested that those PTM antibodies have high specific accumulation for breast cancer in tumor xenograft mice. Overall, our data suggest that the PTM ELISA microarray platform is a promising tool for discovery and evaluation of biomarkers that have potential for the early detection of breast cancer.