The global hemostats and tissue sealants market was sized near USD 6931.42 million in 2023 in terms of value. Hemostatic agents and tissue sealants are frequently employed in reconstruction during surgical repair, to stop excessive blood loss. Thrombin sealant, fibrin glue, bovine serum/albumin/glutaraldehyde, and gelatin matrix are some major products offered in the market. Each of these agents has a unique mechanism, price, and use. There are different types of diseases that are treated by different surgeries, but surgery has long been concerned about blood loss. There have long been techniques to stop bleeding and mend wounds. Numerous hemostatic medications and tissue sealants have been created during the past 20 years and are being utilized in a variety of surgical specialties. Hemostatic agents are designed to halt bleeding either through mechanical means or by enhancing the natural coagulation cascade. On the other hand, tissue sealants are products that adhere to and seal defects in tissue, promoting hemostasis and facilitating the healing process. The hemostatic agents function by physically blocking or promoting clot formation, while tissue sealants work by creating a barrier that supports tissue repair and regeneration. The selection of the appropriate agent depends on the specific clinical situation and the patient's individual needs. Healthcare professionals must carefully consider the characteristics of each product and their potential benefits and risks when deciding on the most appropriate treatment option.